Immunocytochemical profiles of inferior colliculus neurons in the rat and their changes with aging

0385992 - ÚEM 2013 RIV CH eng J - Článek v odborném periodiku
Ouda, Ladislav - Syka, Josef
Immunocytochemical profiles of inferior colliculus neurons in the rat and their changes with aging.
Frontiers in Neural Circuits. Roč. 6, č. 68 (2012), s. 1-14. E-ISSN 1662-5110
Grant CEP: GA ČR(CZ) GAP304/12/1342; GA ČR(CZ) GBP304/12/G069
Výzkumný záměr: CEZ:AV0Z50390703
Institucionální podpora: RVO:68378041
Klíčová slova: inferior colliculus * GABA * parvalbumin
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.333, rok: 2012

A review summarizing distribution and age-related changes of GABAergic neurons and neurons expressing calcium binding proteins (CBPs – parvalbumin, calbindin, calretinin). The expression of glutamate decarboxylase (GAD) (a key enzyme for GABA synthesis) and calcium binding proteins in the neuron of the rat IC undergoes significant decline with aging. Similar age-related changes in GAD and CBPs expression are present in the IC of two rat strains with differently preserved inner ear function up to late senescence (Long-Evans and Fischer 344), which suggests that these changes do not depend exclusively on peripheral deafferentation but are, at least partially, of central origin.
Trvalý link: http://hdl.handle.net/11104/0215985