Počet záznamů: 1
Novel antimicrobial peptides and their application
- 1.0385984 - ÚOCHB 2013 RIV eng P - Patentový dokument
Čeřovský, Václav - Slaninová, Jiřina - Hovorka, Oldřich - Cvačka, Josef - Voburka, Zdeněk - Fučík, Vladimír - Bednárová, Lucie - Votruba, Ivan - Borovičková, Lenka - Turánek, J.
Novel antimicrobial peptides and their application.
2012. Vlastník: Ústav organické chemie a biochemie Akademie věd ČR, v. v. i. Datum udělení patentu: 25.04.2012. Číslo patentu: EP2265631
Grant CEP: GA ČR GA203/08/0536
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: D-amino acid * antimicrobial peptides * analogs
Kód oboru RIV: CC - Organická chemie
http://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20120425&DB=EPODOC&locale=en_EP&CC=EP&NR=2265631B1&KC=B1&ND=4UK
This invention involves four novel peptides of the formulas I, II, III a IV isolated from natural sources and their synthetic analogs of general formula V and VI, where R 1 represents acyl, alkyl or unprotected amino group, R 2 represents amid, substituted amid, unprotected carboxylic group or ester, Xaa represents, independently from each other, proteinogenic amino acid, D-amino acid, non-standard amino acid or amino acid with the side chain modification, n means position of the amino acid replacement and m means the number of the replacements in the peptide chain, and their applications as antimicrobial, antiviral, antifungal, antiparasitic and anticancer compounds. Therefore, they are practical for the production of medication for the treatment of microbial, parasitic and fungal diseases and for the cancer treatment.; Formulas for summary: H-Gly-Phe-Leu-Ser-Ile-Leu-Lys-Lys-Val-Leu-Pro-Lys-Val-Met-Ala-His-Met-Lys-NH2 (I) H-VaI-Asn-Trp-Lys-Lys-VaI-Leu-GIy-Lys-IIe-IIe-Lys-VaI-AIa-Lys-NH2 (II) H-VaI-Asn-Trp-Lys-Lys-IIe-Leu-GIy-Lys-IIe-IIe-Lys-VaI-AIa-Lys-NH2 (III) H-Val-Asn-Trp-Lys-Lys-Ile-Leu-Gly-Lys-Ile-Ile-Lys-Val-Val-Lys-NH2 (IV) R1-[Xaan]m -Gly-Phe-Leu-Ser-Ile-Leu-Lys-Lys-Val-Leu-Pro-Lys-Val-Met-Ala-His-Met-Lys-R2 (V) R1-[Xaan]m-Val-Asn-Trp-Lys-Lys-Ile-Leu-Gly-Lys-Ile-Ile-Lys-Val-Val-Lys-R2 (VI).
Trvalý link: http://hdl.handle.net/11104/0215408
Počet záznamů: 1