Počet záznamů: 1  

Neurological diseases as primary gliopathies: a reassessment of neurocentrism

  1. 1.
    0385666 - ÚEM 2013 RIV GB eng J - Článek v odborném periodiku
    Verkhratsky, A. - Sofroniew, M. V. - Messing, A. - deLanerolle, N. C. - Rempe, D. - Rodríguez Arellano, Jose Julio - Nedergaard, M.
    Neurological diseases as primary gliopathies: a reassessment of neurocentrism.
    ASN Neuro. Roč. 4, č. 3 (2012), e00082. ISSN 1759-0914. E-ISSN 1759-0914
    Grant CEP: GA ČR GA309/09/1696; GA ČR(CZ) GAP304/11/0184; GA ČR GA305/08/1384; GA ČR GA309/08/1381
    Výzkumný záměr: CEZ:AV0Z50390703
    Institucionální podpora: RVO:68378041
    Klíčová slova: aging * astrocyte * brain
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.638, rok: 2012

    Diseases of the human brain are almost universally attributed to malfunction or loss of nerve cells. We endeavour a broad overviewing of the progress in the field and forward the idea that loss of homoeostatic astroglial function leads to an acute loss of neurons in the setting of acute insults such as ischaemia, whereas more subtle dysfunction of astrocytes over periods of months to years contributes to epilepsy and to progressive loss of neurons in neurodegenerative diseases. The majority of therapeutic drugs currently in clinical use target neuronal receptors, channels or transporters. Future therapeutic efforts may benefit by a stronger focus on the supportive homoeostatic functions of astrocytes.
    Trvalý link: http://hdl.handle.net/11104/0215095

     
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.