Neurotransmitters and Integration in Neuronal-Astroglial Networks

0385638 - ÚEM 2013 RIV US eng J - Článek v odborném periodiku
Verkhratsky, Alexei - Rodríguez Arellano, Jose Julio - Parpura, V.
Neurotransmitters and Integration in Neuronal-Astroglial Networks.
Neurochemical Research. Roč. 37, č. 11 (2012), s. 2326-2338. ISSN 0364-3190. E-ISSN 1573-6903
Grant CEP: GA ČR GA309/09/1696; GA ČR GA305/08/1384
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: astrocyte * calcium * neurone
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 2.125, rok: 2012

Two major neural cell types, glia, astrocytes in particular, and neurones can release chemical transmitters that act as soluble signalling compounds for intercellular communication. While neurones rely predominately on the immediate entry of Ca(2+) from the extracellular space to the cytosol in this process, astrocytes support their cytosolic Ca(2+) increases by appropriating this ion from the intracellular endoplasmic reticulum store and extracellular space. Moreover, chemical transmission is essential not only for homocellular, but also for heterocellular bi-directional communication in the brain. Further detailed understanding of chemical transmission will aid our comprehension of the brain (dys)function in heath and disease.
Trvalý link: http://hdl.handle.net/11104/0215097