Genetic profile of genes involved in cell cycle control: The risk of sporadic colorectal cancer in the Czech Republic

0385620 - ÚEM 2013 RIV DE eng B - Monografie kniha jako celek
Poláková, Veronika
Genetic profile of genes involved in cell cycle control: The risk of sporadic colorectal cancer in the Czech Republic.
Saarbrucken: LAP LAMBERT Academic Publishing, 2012. 92 s. ISBN 978-3-8465-8563-4
Grant CEP: GA ČR GA310/07/1430
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: colorectal cancer * polymorphism * TP53 gene
Kód oboru RIV: EB - Genetika a molekulární biologie

The Czech Republic has one of the highest incidence rates of colorectal cancer (CRC) worldwide. In the present study, we genotyped common variants in cell cycle and DNA repair genes to assess the influence of genetic variation on the CRC risk, in 614 hospital-based CRC cases and 614 matched controls. Despite a tendency towards a differential distribution of the variant allele frequencies for some cell cycle polymorphisms, none was significantly associated with CRC risk. We observed a differential distribution between cases and controls of major haplotypes arising from the four analysed variants in the TP53 gene.
Trvalý link: http://hdl.handle.net/11104/0007320