Functional, genetic and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas

0385619 - ÚEM 2013 RIV US eng J - Článek v odborném periodiku
Slyšková, Jana - Korenková, Vlasta - Collins, A. R. - Procházka, Pavel - Vodičková, Ludmila - Švec, Jiří - Lipská, L. - Levý, M. - Schneiderová, M. - Liška, V. - Holubec, L. - Kumar, R. - Souček, P. - Naccarati, Alessio - Vodička, Pavel
Functional, genetic and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas.
Clinical Cancer Research. Roč. 18, č. 21 (2012), s. 5878-5887. ISSN 1078-0432. E-ISSN 1557-3265
Grant CEP: GA ČR GAP304/12/1585; GA ČR(CZ) GAP304/10/1286; GA MZd NT12025
Grant ostatní: UICC(XE) ICR/11/068/2011; EEA-research fund:(NO) B/CZ0046/40031
Výzkumný záměr: CEZ:AV0Z50390512
Institucionální podpora: RVO:68378041 ; RVO:86652036
Klíčová slova: DNA repair capacity * DNA repair gene expression * methylation
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 7.837, rok: 2012

For the first time, we have evaluated both base and nucleotide excision repair capacities in human colon biopsies to study their participation in colorectal tumorigenesis. Our complex analysis showed that tumor cells are not deficient in studied pathways, but rather follow patterns characteristic for each individual and are comparable with adjacent tissue. This study further shows the feasibility of DRC evaluation in human solid tissues, representing a complex marker of multigene DNA repair processes.
Trvalý link: http://hdl.handle.net/11104/0007411