The serotonergic system in ageing and Alzheimer's disease.

0385396 - ÚEM 2013 RIV GB eng J - Článek v odborném periodiku
Rodríguez Arellano, Jose Julio - Noristani, H. N. - Verkhratsky, A.
The serotonergic system in ageing and Alzheimer's disease.
Progress in Neurobiology. Roč. 99, č. 1 (2012), s. 15-41. ISSN 0301-0082. E-ISSN 1873-5118
Grant CEP: GA ČR GA309/09/1696; GA ČR GA305/08/1384; GA ČR GA309/08/1381; GA ČR(CZ) GAP304/11/0184
Výzkumný záměr: CEZ:AV0Z50390703
Institucionální podpora: RVO:68378041
Klíčová slova: dementia * serotonin * hippocampus
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 9.035, rok: 2012

Alzheimer's disease (AD) is one of the major neurodegenerative diseases that deteriorates cognitive functions and primarily affects associated brain regions involved in learning and memory, such as the neocortex and the hippocampus. We present a comprehensive overview of the role of serotonergic neurotransmission in brain development, maturation and ageing, discuss its role in higher brain function and provide an in depth account of pathological modifications of serotonergic transmission in neurological diseases and AD.
Trvalý link: http://hdl.handle.net/11104/0215098