An Epigenetic Model for Pigment Patterning Based on Mechanical and Cellular Interactions

0385246 - ÚPT 2013 RIV US eng J - Článek v odborném periodiku
Caballero, L. - Benitez, M. - Alvarez-Buylla, E. R. - Hernandez, S. - Arzola, Alejandro V. - Cocho, G.
An Epigenetic Model for Pigment Patterning Based on Mechanical and Cellular Interactions.
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Additional Title Information. Roč. 318, č. 3 (2012), s. 209-223. ISSN 1552-5007. E-ISSN 1552-5015
Institucionální podpora: RVO:68081731
Klíčová slova: epithelial-mesenchymal transitions * neural crest * traction forces * morphogenesis
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 2.123, rok: 2012

Pigment patterning in animals generally occurs during early developmental stages and has ecological, physiological, ethological, and evolutionary significance. Despite the relative simplicity of color patterns, their emergence depends upon multilevel complex processes. Thus, theoretical models have become necessary tools to further understand how such patterns emerge. Recent studies have reevaluated the importance of epigenetic, as well as genetic factors in developmental pattern formation. Yet epigenetic phenomena, specially those related to physical constraints that might be involved in the emergence of color patterns, have not been fully studied. In this article, we propose a model of color patterning in which epigenetic aspects such as cell migration, celltissue interactions, and physical and mechanical phenomena are central. This model considers that motile cells embedded in a fibrous, viscoelastic matrixmesenchymecan deform it in such a way that tension tracks are formed. We postulate that these tracks act, in turn, as guides for subsequent cell migration and establishment, generating long-range phenomenological interactions. We aim to describe some general aspects of this developmental phenomenon with a rather simple mathematical model. Then we discuss our model in the context of available experimental and morphological evidence for reptiles, amphibians, and fishes, and compare it with other patterning models. We also put forward novel testable predictions derived from our model, regarding, for instance, the localization of the postulated tension tracks, and we propose new experiments. Finally, we discuss how the proposed mechanism could constitute a dynamic patterning module accounting for pattern formation in many animal lineages.
Trvalý link: http://hdl.handle.net/11104/0214571