YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation

0385215 - FGÚ 2013 RIV US eng J - Článek v odborném periodiku
Stibůrek, L. - Česneková, J. - Kostková, O. - Fornůsková, D. - Vinšová, K. - Wenchich, L. - Houštěk, Josef - Zeman, J.
YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation.
Molecular Biology of the Cell. Roč. 23, č. 6 (2012), s. 1010-1023. ISSN 1059-1524. E-ISSN 1939-4586
Grant CEP: GA MŠMT(CZ) 1M0520
Grant ostatní: Univerzita Karlova(CZ) 277511; GA ČR(CZ) GPP305/10/P414
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: mitochondria * respiratory chain * AAA proteases * YME1L * apoptosis * HEK293 cells
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 4.803, rok: 2012

We studied the functional involvement of human YME1L in mitochondrial biogenesis and homeostasis using stable RNAi and expression experiments in HEK293 cells. We found that YME1L performs proteolytic control of mitochondrial OXPHOS biogenesis, functions antiapoptotic and is required for normal cell proliferation. Our results stress the importance of mitochondrial protein quality control for mitochondrial and cellular integrity and demonstrate novel mechanisms controlling respiratory chain biogenesis
Trvalý link: http://hdl.handle.net/11104/0214548