Effect of endothelin-1 on the excitability of rat cortical and hippocampal slices in vitro

0385207 - FGÚ 2013 RIV CZ eng J - Článek v odborném periodiku
Konopková, Renata - Világi, I. - Borbély, S. - Kubová, Hana - Otáhal, Jakub
Effect of endothelin-1 on the excitability of rat cortical and hippocampal slices in vitro.
Physiological Research. Roč. 61, č. 2 (2012), s. 215-219. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MŠMT(CZ) LC554; GA AV ČR(CZ) 1QS501210509; GA ČR(CZ) GD305/08/H037
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: Endothelin-1 * excitability * hippocampus * somatosensory cortex * rat * epileptogenesis
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 1.531, rok: 2012

Endothelin-1 (ET-1) is a neuroactive protein produced in most brain cell types and participates in regulation of cerebral blood flow and blood pressure. In addition to its vascular effects, ET-1 affects synaptic and nonsynaptic neuronal and glial functions. Direct application of ET-1 to the hippocampus of immature rats results in cerebral ischemia, acute seizures, and epileptogenesis. Here, we investigated whether ET-1 itself modifies the excitability of hippocampal and cortical circuitry and whether acute seizures observed in vivo are due to nonvascular actions of ET-1
Trvalý link: http://hdl.handle.net/11104/0214540