Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity

0384913 - ÚOCHB 2013 RIV US eng J - Článek v odborném periodiku
Novák, Z. - Chlebek, J. - Opletal, L. - Jiroš, Pavel - Macáková, K. - Kuneš, J. - Cahlíková, L.
Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity.
Natural Product Communications. Roč. 7, č. 7 (2012), s. 859-860. ISSN 1934-578X. E-ISSN 1555-9475
Grant ostatní: SVV UK(CZ) 265002; SVV UK(CZ) 265001; FRVŠ(CZ) 664/2011; UNCE UK(CZ) 17/2012/
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: Corydalis cava * corylucinine * 8-trichloromethyl-7,8-dihydropalmatine * acetylcholinesterase * butyrylcholinesterase * Alzheimer's disease
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 0.956, rok: 2012

A new benzyldihydroisoquinoline alkaloid (1) was isolated from the tubers of Corydalis cava and named corylucinine. Additionally, 8-trichloromethyl-7,8-dihydropalmatine (2), an isolation artifact of tetrahydropalmatine, was obtained. The structures were established by spectroscopic (including 2D NMR and optical rotation) and HR-ESI-MS methods. Both compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBtiChE) inhibitory activity. In comparison with the used standards, both compounds showed only moderate inhibitory activity against HuAChE (IC50, (HuAChE) = 127.6 +/- 5.2 mu M for 1, and IC50, (HuAchE) = 82.9 +/- 3.9 mu M for 2) and none against HuBuChE.
Trvalý link: http://hdl.handle.net/11104/0214376