Non-fouling hydrogels of 2-hydroxyethyl methacrylate and zwitterionic carboxybetaine (meth)acrylamides

0384769 - ÚMCH 2013 RIV US eng J - Článek v odborném periodiku
Kostina, Nina Yu. - Rodriguez-Emmenegger, Cesar - Houska, Milan - Brynda, Eduard - Michálek, Jiří
Non-fouling hydrogels of 2-hydroxyethyl methacrylate and zwitterionic carboxybetaine (meth)acrylamides.
Biomacromolecules. Roč. 13, č. 12 (2012), s. 4164-4170. ISSN 1525-7797. E-ISSN 1526-4602
Grant CEP: GA AV ČR KAN200520804; GA ČR GAP205/12/1702; GA ČR GAP106/12/1451
Výzkumný záměr: CEZ:AV0Z40500505
Institucionální podpora: RVO:61389013
Klíčová slova: zwitterionic hydrogels * non-fouling properties * carboxybetaine
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 5.371, rok: 2012

Five poly(betaine) brushes were prepared, and their resistance to blood plasma fouling was studied. Two carboxybetaines monomers were copolymerized with 2-hydroxyethyl methacrylate (HEMA) to prepare novel hydrogels. By increasing the content of the zwitterionic comonomer, a 4-fold increase in the water content could be achieved while retaining mechanical properties close to the widely used poly(HEMA) hydrogels. All hydrogels showed an unprecedentedly low fouling from blood plasma. Remarkably, by copolymerization with 10 mol % of carboxybetaine acrylamide, hydrogels fully resistant to blood plasma were prepared.
Trvalý link: http://hdl.handle.net/11104/0216114