Lipases as Tools in the Synthesis of Prodrugs from Racemic 9-(2,3-Dihydroxypropyl)adenine

0384593 - ÚOCHB 2013 RIV CH eng J - Článek v odborném periodiku
Brabcová, Jana - Blažek, Jiří - Janská, Lucie - Krečmerová, Marcela - Zarevúcka, Marie
Lipases as Tools in the Synthesis of Prodrugs from Racemic 9-(2,3-Dihydroxypropyl)adenine.
Molecules. Roč. 17, č. 12 (2012), s. 13813-13824. E-ISSN 1420-3049
Grant ostatní: AV ČR(CZ) M200551203
Institucionální podpora: RVO:61388963
Klíčová slova: lipase * transesterification * prodrug * immobilization of enzymes
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 2.428, rok: 2012

Lipases from Geotrichum candidum 4013 (extracellular lipase and cell-bound lipase) were immobilized by adsorption on chitosan beads. The enzyme preparations were tested in the synthesis of ester prodrugs from racemic 9-(2,3-dihydroxypropyl)adenine in dimethylformamide with different vinyl esters (acetate, butyrate, decanoate, laurate, palmitate). The transesterification activities of these immobilized enzymes were compared with commercially available lipases (lipase from hog pancreas, Aspergillus niger, Candida antarctica, Pseudomonas fluorescens).
Trvalý link: http://hdl.handle.net/11104/0214185