Polymer carriers for anticancer drugs targeted to EGF receptor

0384522 - ÚMCH 2013 RIV DE eng J - Článek v odborném periodiku
Studenovský, Martin - Pola, Robert - Pechar, Michal - Etrych, Tomáš - Ulbrich, Karel - Kovář, Lubomír - Kabešová, Martina - Říhová, Blanka
Polymer carriers for anticancer drugs targeted to EGF receptor.
Macromolecular Bioscience. Roč. 12, č. 12 (2012), s. 1714-1720. ISSN 1616-5187. E-ISSN 1616-5195
Grant CEP: GA AV ČR IAAX00500803
Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z50200510
Institucionální podpora: RVO:61389013 ; RVO:61388971
Klíčová slova: biocompatibility * EGFR * peptides
Kód oboru RIV: CD - Makromolekulární chemie; EC - Imunologie (MBU-M)
Impakt faktor: 3.742, rok: 2012

A novel actively targeted polymer carrier for anticancer drugs based on an N-(2-hydroxypropyl)methacrylamide copolymer (PHPMA) is proposed. An oligopeptide sequence GE7, attached to the polymer, is a specific ligand for the EGF receptor overexpressed on most tumor cells. Co-attachment of selected chemotherapeutics will therefore lead to formation of tumorspecific polymer therapeutics, further enhanced by the EPR effect. FACS measurements prove elevated binding activity of the fluorescently labeled PHPMA/GE7 conjugate in EGFR-rich cells (FaDu, MCF-7), compared to conjugates of scrambled peptides. Cell lines with low EGFR level (SW620, B16F10) bind the GE7 conjugate significantly less.
Trvalý link: http://hdl.handle.net/11104/0216062