Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part II. Chromosomal aberrations and oxidative stress

0384434 - ÚEM 2014 RIV GB eng J - Článek v odborném periodiku
Rössner ml., Pavel - Rössnerová, Andrea - Špátová, Milada - Beskid, Olena - Uhlířová, Kateřina - Líbalová, Helena - Solanský, I. - Topinka, Jan - Šrám, Radim
Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part II. Chromosomal aberrations and oxidative stress.
Mutagenesis. Roč. 28, č. 1 (2013), s. 97-106. ISSN 0267-8357. E-ISSN 1464-3804
Grant CEP: GA MŽP(CZ) SP/1B3/8/08; GA MŠMT 2B08005; GA ČR GAP503/11/0084
Výzkumný záměr: CEZ:AV0Z50390703
Institucionální podpora: RVO:68378041
Klíčová slova: air pollution * benzo[a]pyrene * benzene
Kód oboru RIV: DN - Vliv životního prostředí na zdraví
Impakt faktor: 3.497, rok: 2013

The study indentified the effect of exposure to benzo[a]pyrene, particulate matter (PM2.5) and benzene on oxidative stress markers (8-oxodG, 15-F2t-IsoP and protein carbonyls) and cytogenetic parameters (stable and unstable chromosomal aberrations). The samples were collected from subjects from the Ostrava region and Prague in three seasons (winter 2009, summer 2009, and winter 2010). Despite several fold higher concentrations of air pollutants in the Ostrava region, the levels of stable aberrations were mostly comparable in both locations. The frequency of unstable aberrations was unexpectedly significantly lower in the Ostrava region subjects in both seasons of 2009. Urinary excretion of 8-oxodG did not differ between locations in either season. Lipid peroxidation measured as levels of 15-F2t-IsoP in blood plasma was elevated in the Ostrava subjects sampled in 2009. Protein oxidation was higher in Prague samples collected in summer 2009. Multivariate analyses showed a negative association between the frequency unstable aberrations and concentrations of B[a]P and PM2.5 in both regions. A positive relationship was observed between lipid peroxidation and air pollution; protein oxidation seems to be positively affected by PM2.5 in both regions.
Trvalý link: http://hdl.handle.net/11104/0215208