Vasopressin-induced intracellular Ca2+ concentration responses in non-neuronal cells of the rat dorsal root ganglion

0383866 - ÚEM 2013 RIV NL eng J - Článek v odborném periodiku
Moriya, T. - Kayano, T. - Kitamura, N. - Hosaka, Y. Z. - Asano, A. - Forostyak, Oksana - Verkhratsky, Alexei - Viero, C. - Dayanithi, Govindan - Toescu, E.C. - Shibuya, I.
Vasopressin-induced intracellular Ca2+ concentration responses in non-neuronal cells of the rat dorsal root ganglion.
Brain Research. Roč. 1483, 5 NOV (2012), s. 1-12. ISSN 0006-8993. E-ISSN 1872-6240
Grant CEP: GA ČR(CZ) GAP303/11/0192
Výzkumný záměr: CEZ:AV0Z50390703
Institucionální podpora: RVO:68378041
Klíčová slova: neuropeptides * peripheral nervous system * glia
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 2.879, rok: 2012

Arginine-vasopressin (AVP) is a nonapeptide of hypothalamic origin that has been shown to exert many important cognitive and physiological functions in neurons and terminals of both the central and peripheral nervous system. Here we report for the first time that AVP induced an increase in intracellular Ca2+ concentration in non-neuronal cells isolated from the rat dorsal root ganglion (DRG) and cultured in vitro. Our results suggest that AVP modulates the activity of DRG glial cells via activation of V1a receptor.
Trvalý link: http://hdl.handle.net/11104/0007310