Segregation of calcium signalling mechanisms in magnocellular neurones and terminals

0383855 - ÚEM 2013 RIV DE eng J - Článek v odborném periodiku
Dayanithi, Govindan - Forostyak, Oksana - Ueta, Y. - Verkhratsky, Alexei - Toescu, E.C.
Segregation of calcium signalling mechanisms in magnocellular neurones and terminals.
Cell Calcium. Roč. 51, 3-4 (2012), s. 293-299. ISSN 0143-4160. E-ISSN 1532-1991
Grant CEP: GA ČR(CZ) GAP303/11/0192
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: Ca2+ stores * Mitochondria * Endoplasmic reticulum
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 4.327, rok: 2012

The present study has highlighted the mechanisms involved in Ca2+ homeostasis and Ca2+ clearance processes both in the cell bodies and the nerve terminals of the vasopressin (AVP) and oxytocin (OT) neurones in the supraoptic nucleus, using both the normal rat model and the recently developed transgenic rat with specific fluorescence labelling for AVP and OT. The physiological significance of the complexity of Ca2+ homeostatic mechanisms in the somatodendritic region of supraoptic neurones and their terminals can be multifaceted, attributable, in major part, to their specialized electrical activity and Ca2+-dependent neurohormone release.
Trvalý link: http://hdl.handle.net/11104/0213667