Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue

0383116 - ÚMG 2013 RIV SK eng J - Článek v odborném periodiku
Krausová, Michaela - Kořínek, Vladimír
Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue.
Neoplasma. Roč. 59, č. 6 (2012), s. 708-718. ISSN 0028-2685. E-ISSN 1338-4317
Grant CEP: GA ČR GAP305/11/1780; GA ČR GAP305/12/2347; GA ČR GAP304/11/1252; GA ČR GD204/09/H058
Klíčová slova: colorectal cancer * epithelium * gut * intestine * mouse models * stem cells
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 1.574, rok: 2012

Intestinal homeostasis is a complex and tightly regulated process governed by a variety of signalling pathways that balance cell proliferation and differentiation. As revealed by extensive use of defined mouse models, perturbations within the signalling circuitry trigger initial expansion of premalignant cells. In this review, we attempt to summarise recent advances in the knowledge of the cellular signalling mechanisms that drive tumorigenesis in the human and mouse intestine.
Trvalý link: http://hdl.handle.net/11104/0216396