Age-related changes in the acoustic startle reflex in Fischer 344 and Long Evans rats

0383080 - ÚEM 2013 RIV US eng J - Článek v odborném periodiku
Rybalko, Natalia - Bureš, Zbyněk - Burianová, Jana - Popelář, Jiří - Poon, P. W. F. - Syka, Josef
Age-related changes in the acoustic startle reflex in Fischer 344 and Long Evans rats.
Experimental Gerontology. Roč. 47, č. 12 (2012), s. 966-973. ISSN 0531-5565. E-ISSN 1873-6815
Grant CEP: GA ČR(CZ) GAP304/12/1342; GA ČR(CZ) GBP304/12/G069; GA ČR(CZ) GCP303/11/J005
Výzkumný záměr: CEZ:AV0Z50390512
Institucionální podpora: RVO:68378041
Klíčová slova: aging * acoustic startle response * prepulse inhibition
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.911, rok: 2012

Hearing thresholds, the strength of the acoustic startle responses and the efficiency of the prepulse inhibition were assessed in young, middle-aged, and aged Long Evans and Fischer 344 rats. Fischer 344 rats showed larger age-related hearing threshold shifts and lower amplitudes of startle responses at an earlier age than in Long Evans rats. A reduction of the prepulse inhibition was observed in aged rats of both strains. The results indicate that the acoustic startle response may serve as an indicator of central presbycusis.
Trvalý link: http://hdl.handle.net/11104/0007501