Minimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane

0383074 - ÚEM 2013 RIV GB eng J - Článek v odborném periodiku
Buckiová, Daniela - Ranjan, S. - Newman, T. A. - Johnston, A. H. - Sood, R. - Kinnunen, P. K. J. - Popelář, Jiří - Chumak, Tetyana - Syka, Josef
Minimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane.
Nanomedicine. Roč. 7, č. 9 (2012), s. 1339-1354. ISSN 1743-5889. E-ISSN 1748-6963
Grant CEP: GA ČR GA309/07/1336; GA MŠMT(CZ) LC554
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: nanoparticles * cochlea * drug delivery
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 5.260, rok: 2012

Liposome and polymersome nanoparticles were tested as potential tools for drug delivery to the cochlea via application onto the round window membrane in adult mice. The results demonstrated that liposome and polymersome nanoparticles are capable of carrying a payload into the inner ear that elicits a biological effect, with consequences measurable by a functional readout.
Trvalý link: http://hdl.handle.net/11104/0007210