Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury

0383008 - ÚEM 2013 RIV NZ eng J - Článek v odborném periodiku
Vaněček, Václav - Zablotskyy, Vitaliy A. - Forostyak, Serhiy - Růžička, Jiří - Herynek, V. - Babič, Michal - Jendelová, Pavla - Kubinová, Šárka - Dejneka, Alexandr - Syková, Eva
Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury.
International Journal of Nanomedicine. Roč. 7, 16 Jul (2012), s. 3719-3730. E-ISSN 1178-2013
Grant CEP: GA ČR(CZ) GAP304/12/1370; GA ČR GAP304/11/0731; GA ČR(CZ) GAP304/11/0189; GA ČR GAP304/11/0653; GA AV ČR IAA500390902
Výzkumný záměr: CEZ:AV0Z50390703; CEZ:AV0Z10100522; CEZ:AV0Z40500505
Klíčová slova: nanoparticles * mesenchymal stem cells * magnetic targeting
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy; BM - Fyzika pevných látek a magnetismus (FZU-D); FH - Neurologie, neurochirurgie, neurovědy (UMCH-V)
Impakt faktor: 3.463, rok: 2012

The aim of this study was to evaluate the targeting of mesenchymal stem cells labeled with superparamagnetic iron oxide nanoparticles to the site of a spinal cord injury by means of a magnetic implant. We monitored both the distribution and the number of cells in the lesion site after their intrathecal administration and the effect of the magnetic implant on cell transplantation. The cell distribution correlated with the calculated distribution of magnetic forces exerted on the transplanted cells in the subarachnoid space and the lesion site. Our results showed that the targeting efficiency can be increased by using magnets that produce spatially modulated stray fields. We suggested a mathematical model of cell targeting kinetics and analyzed those parameters of the magnetic system critical for efficient cell targeting.
Trvalý link: http://hdl.handle.net/11104/0213081