Sperm Cells Induce Distinct Cytokine Response in Peripheral Mononuclear Cells from Infertile Women with Serum Anti-Sperm Antibodies

0382246 - MBÚ 2013 RIV US eng J - Článek v odborném periodiku
Kverka, Miloslav - Ulčová-Gallová, Z. - Bártová, J. - Cibulka, J. - Bibková, K. - Mičanová, Z. - Tlaskalová-Hogenová, Helena
Sperm Cells Induce Distinct Cytokine Response in Peripheral Mononuclear Cells from Infertile Women with Serum Anti-Sperm Antibodies.
PLoS ONE. Roč. 7, č. 8 (2012), e44172. ISSN 1932-6203. E-ISSN 1932-6203
Institucionální podpora: RVO:61388971
Klíčová slova: IMMUNE-RESPONSES * GROWTH-FACTOR * ENDOMETRIOSIS
Kód oboru RIV: EC - Imunologie
Impakt faktor: 3.730, rok: 2012

Anti-sperm antibodies in can markedly reduce the likelihood of natural conception. The etiology of this anti-sperm immunity in human females is unknown. We compared the cytokine response of peripheral blood mononuclear cells (PBMCs) from infertile patients with or without anti-sperm antibodies (ASA) and fertile women.Cellular immune responses to sperm antigens, measured by production of cytokines, differ among infertile women with ASA, infertile women without ASA and healthy women. This difference could play an important role in the initial steps of the infertility pathogenesis.
Trvalý link: http://hdl.handle.net/11104/0212524