Antitumor carboplatin is more toxic in tumor cells when photoactivated: enhanced DNA binging

0381591 - BFÚ 2013 RIV DE eng J - Článek v odborném periodiku
Mlčoušková, Jarmila - Štěpánková, Jana - Brabec, Viktor
Antitumor carboplatin is more toxic in tumor cells when photoactivated: enhanced DNA binging.
Journal of Biological Inorganic Chemistry. Roč. 17, č. 6 (2012), s. 891-898. ISSN 0949-8257. E-ISSN 1432-1327
Grant CEP: GA ČR(CZ) GD301/09/H004; GA ČR(CZ) GAP301/10/0598
Výzkumný záměr: CEZ:AV0Z50040702
Klíčová slova: carboplatin * photodynamic therapy * DNA
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 3.353, rok: 2012

It was found that carboplatin was converted to species capable of enhanced DNA binding by UVA irradiation and consequently its toxicity in cancer cells was markedly enhanced. Recent advances in laser and fiber-optic technologies make it possible to irradiate also internal organs with light of highly defined intensity and wavelength. Thus, carboplatin is a candidate for use in photoactivated cancer chemotherapy.
Trvalý link: http://hdl.handle.net/11104/0212022