Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and pluronic F127

0381219 - ÚMCH 2013 RIV DE eng J - Článek v odborném periodiku
Pánek, Jiří - Filippov, Sergey K. - Hrubý, Martin - Rabyk, Mariia - Bogomolova, Anna - Kučka, Jan - Štěpánek, Petr
Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and pluronic F127.
Macromolecular Rapid Communications. Roč. 33, č. 19 (2012), s. 1683-1689. ISSN 1022-1336. E-ISSN 1521-3927
Grant CEP: GA ČR GA202/09/2078; GA ČR GPP207/10/P054
Grant ostatní: AV ČR(CZ) M200501201
Program: M
Výzkumný záměr: CEZ:AV0Z40500505
Institucionální podpora: RVO:61389013
Klíčová slova: nanoparticles * pluronic F127 * poly(2-alkyl-2- oxazoline)s
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 4.929, rok: 2012

We synthesized statistical poly(2-isopropyl-2-oxazoline– co –2-butyl-2-oxazolines) (POXs) that are molecularly dissolved below their cloud point temperature in aqueous milieu and are incorporated into micellar nanoparticles of biocompatible Pluronic F127 (F127) after heating their solution above transition temperature, T tr . A functional comonomer 2-(but-3-enyl)-2-oxazoline copolymerized into one of the POXs (polymer E) allows introduction of fenolic moieties and subsequent radionuclide labeling with iodine-125. Self-assembly of the polymer E with F127 leads to formation of radioactive nanoparticles with hydrodynamic diameter 20 nm in aqueous solution by heating to 37° C. The nanoparticles are intended to be used as radioimaging tool in solid tumor diagnostics.
Trvalý link: http://hdl.handle.net/11104/0211740