Počet záznamů: 1
The natural stilbenoid pinosylvin and activated neutrophils: effects on oxidative burst, protein kinase C, apoptosis and efficiency in adjuvant arthritis
- 1.0381109 - ÚOCHB 2013 RIV US eng J - Článek v odborném periodiku
Jančinová, V. - Perečko, T. - Nosál, R. - Harmatha, Juraj - Šmidrkal, J. - Drábiková, K.
The natural stilbenoid pinosylvin and activated neutrophils: effects on oxidative burst, protein kinase C, apoptosis and efficiency in adjuvant arthritis.
Acta Pharmacologica Sinica. Roč. 33, č. 10 (2012), s. 1285-1292. ISSN 1671-4083. E-ISSN 1745-7254
Grant CEP: GA ČR(CZ) GA203/07/1227
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: pinosylvin * reactive oxygen species * adjuvant arthritis
Kód oboru RIV: FR - Farmakologie a lékárnická chemie
Impakt faktor: 2.354, rok: 2012
The effects of the naturally occurring stilbenoid pinosylvin on neutrophil activity in vitro and in experimental arthritis are reported. Pinosylvin significantly decreased the formation of oxidants, both extra- and intra-cellularly, and effectively inhibited protein kinase C activation. Pinosylvin administration decreased the number of neutrophils and significantly reduced the amount of reactive oxygen species in blood. Pinosylvin, as an effective inhibitor of neutrophil activity, is potentially useful as a complementary medicine associated with medicaments prescribed for treating persistent inflammation.
Trvalý link: http://hdl.handle.net/11104/0211649
Počet záznamů: 1