Počet záznamů: 1
3 alpha 5 beta-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia
- 1.0381028 - FGÚ 2013 RIV NL eng J - Článek v odborném periodiku
Valeš, Karel - Rambousek, Lukáš - Holubová, Kristína - Svoboda, Jan - Bubeníková-Valešová, V. - Chodounská, Hana - Vyklický ml., Ladislav - Stuchlík, Aleš
3 alpha 5 beta-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia.
Behavioural Brain Research. Roč. 235, č. 1 (2012), s. 82-88. ISSN 0166-4328. E-ISSN 1872-7549
Grant CEP: GA MZd(CZ) NS10365
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823 ; RVO:61388963
Klíčová slova: schizophrenia-like behavior * MK-801 * use-dependent * NMDA antagonist * anxiety * pregnanolone glutamate * Carousel maze
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.327, rok: 2012
We have developed novel neuroactive steroid pregnanolone glutamate (3alpfa5beta-P-Glu). 3alpha5beta-P-Glu acts as a use-dependent NMDA receptor antagonist. 3alpha5beta-P-Glu reversed spatial learning deficit in an animal model of schizophrenia. 3alpha5beta-P-Glu did not influence spatial learning of intact animals. 3alpha5beta-P-Glu may represent procognitive drug without side effects
Trvalý link: http://hdl.handle.net/11104/0211591
Počet záznamů: 1