One-pot build-up procedure for the synthesis of variously substituted purine derivatives

0380853 - ÚOCHB 2013 RIV GB eng J - Článek v odborném periodiku
Dejmek, Milan - Kovačková, Soňa - Zborníková, Eva - Hřebabecký, Hubert - Šála, Michal - Dračínský, Martin - Nencka, Radim
One-pot build-up procedure for the synthesis of variously substituted purine derivatives.
RSC Advances. Roč. 2, č. 17 (2012), s. 6970-6980. E-ISSN 2046-2069
Grant CEP: GA MV VG20102015046
Institucionální podpora: RVO:61388963
Klíčová slova: purines * heterocycles * adenine * guanine
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 2.562, rok: 2012

In this article, we report a one-pot build-up procedure leading to 6-chloro- or 2-amino-6-chloropurines bearing various alkyl or aryl substituents in position N-9. This reaction is simple, fast and effective with up to 96% yields depending on the starting amine. This reaction may be easily combined with further nucleophilic displacement of the C-6 chlorine atom using various reagents, making this procedure very attractive in the field of medicinal chemistry pertaining to compounds based on a purine scaffold.
Trvalý link: http://hdl.handle.net/11104/0211461