Biomedical Science, Engineering and Technology

0380161 - ÚOCHB 2013 RIV HR eng M - Část monografie knihy
Turánek, J. - Mašek, J. - Raška, M. - Ledvina, Miroslav
Application of Liposomes for Construction of Vaccines.
Biomedical Science, Engineering and Technology. Rijeka: InTech, 2012 - (Ghista, D.), s. 653-678. ISBN 978-953-307-471-9
Grant CEP: GA ČR(CZ) GAP304/10/1951; GA AV ČR(CZ) KAN200520703; GA AV ČR KAN200100801
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: liposomes * metallochelation * recombinant vaccines * adjuvants
Kód oboru RIV: CC - Organická chemie
http://www.intechopen.com/books/biomedical-science-engineering-and-technology/application-of-liposomes-for-construction-of-vaccines

The chapter deals with construction recombinant vaccines on liposomal platform. Liposomes are very useful tool for the construction of vaccination systems because offer the possibility to associate or entrap simultaneously more than one type molecule, i.e., co-association of hydrophilic or hydrophobic adjuvants (monophosphoryl lipid A, CpG oligonucleotides, muramyl glycopeptides and their lipophilic analogs with soluble or membrane antigens. A special attention is devoted to non-pyrogenic normuramyl glycopeptides and their lipophilic analogs. Preparation of liposomes presenting metalochelating anchors and grafting of hys-tagged recombinant antigens onto their surface are also broadly discussed.
Trvalý link: http://hdl.handle.net/11104/0210945