Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking

0380084 - FGÚ 2013 RIV NL eng J - Článek v odborném periodiku
Jindřichová, Marie - Kuzyk, Pavlo - Li, S. - Stojilkovic, S. S. - Zemková, Hana
Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking.
Purinergic Signalling. Roč. 8, č. 2 (2012), s. 317-325. ISSN 1573-9538. E-ISSN 1573-9546
Grant CEP: GA AV ČR(CZ) IAA500110910; GA ČR(CZ) GA305/07/0681; GA ČR(CZ) GD305/08/H037; GA MŠMT(CZ) LC554; GA ČR(CZ) GPP304/12/P371
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: purinergic P2X receptors * ATP-gated channels * disulfide bonds * trafficking
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 2.635, rok: 2012

The aim of this study was to understand the role of conserved ectodomain cysteine residues in P2X7 receptor function. Single- and double-point threonine mutants, other than C119T-P2X7, responded to application of BzATP and ATP with small amplitude currents or were practically non-functional. The mutagenesis-induced loss of function was due to decreased cell-surface receptor expression
Trvalý link: http://hdl.handle.net/11104/0210896