Self-assembly of biodegradable copolyester and reactive HPMA-based polymers into nanoparticles as an alternative stealth drug delivery system

0379960 - ÚMCH 2013 RIV GB eng J - Článek v odborném periodiku
Jäger, Eliezer - Jäger, Alessandro - Etrych, Tomáš - Giacomelli, F. C. - Chytil, Petr - Jigounov, Alexander - Putaux, J.-L. - Říhová, Blanka - Ulbrich, Karel - Štěpánek, Petr
Self-assembly of biodegradable copolyester and reactive HPMA-based polymers into nanoparticles as an alternative stealth drug delivery system.
Soft Matter. Roč. 8, č. 37 (2012), s. 9563-9575. ISSN 1744-683X. E-ISSN 1744-6848
Grant CEP: GA AV ČR IAAX00500803; GA ČR GAP208/10/1600
Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z50200510
Institucionální podpora: RVO:61389013 ; RVO:61388971
Klíčová slova: biodegradable nanoparticles * light scattering from polymer nanoparticles * doxorubicin drug release
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie; EC - Imunologie (MBU-M)
Impakt faktor: 3.909, rok: 2012

The surface modification of nanoparticles by physically anchoring hydrophilic biocompatible polymers is a simple and commercially attractive strategy to produce stealth drug delivery nanocarriers. Herein, we report the preparation, characterization and preliminary evaluation of the biological behaviour of polymeric nanoparticles (NPs) comprising a biodegradable poly(butylene succinate-co-butylene dilinoleate) – PBS/PBDL – copolyester and a non-immunogenic and non-toxic hydrophilic N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer. Narrowly distributed sub-100 nm polymeric nanoparticles with stealth properties were successfully prepared by using a combination of interfacial nanoprecipitation and self-assembly. The assemblies were characterized by using complementary scattering techniques and cryo-transmission electron microscopy.
Trvalý link: http://hdl.handle.net/11104/0210802