The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia

0377854 - ÚEM 2013 RIV US eng J - Článek v odborném periodiku
Butenko, Olena - Džamba, Dávid - Benešová, Jana - Honsa, Pavel - Benfenati, V. - Rusňáková, Vendula - Ferroni, S. - Anděrová, Miroslava
The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia.
PLoS ONE. Roč. 7, č. 6 (2012), e39959. ISSN 1932-6203. E-ISSN 1932-6203
Grant CEP: GA ČR GAP303/10/1338; GA MŠMT(CZ) LC554
Grant ostatní: GA ČR(CZ) GD309/08/H079
Výzkumný záměr: CEZ:AV0Z50390512; CEZ:AV0Z50520701
Klíčová slova: ischemia * astrocytes * transient receptor channel
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy; FH - Neurologie, neurochirurgie, neurovědy (BTO-N)
Impakt faktor: 3.730, rok: 2012

The expression of TRPV4 is markedly enhanced in adult rat hippocampal astrocytes of the CA1 region after hypoxia/ischemia coinciding with the development of astrogliosis. This was revealed by immunohistochemical analyses, patch-clamp and calcium imaging measurements both in vitro and in situ. Collectively, we show that TRPV4 channels are involved in ischemia induced calcium entry in reactive astrocytes and thus, might participate in the pathogenic mechanisms of astroglial reactivity following ischemic insult.
Trvalý link: http://hdl.handle.net/11104/0209892