Combination of two chromophores: Synthesis and PDT application of porphyrin-pentamethinium conjugate

0377768 - ÚMG 2013 RIV GB eng J - Článek v odborném periodiku
Bříza, T. - Králová, Jarmila - Cígler, P. - Kejík, Z. - Poučková, P. - Vašek, P. - Moserová, Irena - Martásek, P. - Král, V.
Combination of two chromophores: Synthesis and PDT application of porphyrin-pentamethinium conjugate.
Bioorganic and Medicinal Chemistry Letters. Roč. 22, č. 1 (2012), s. 82-84. ISSN 0960-894X. E-ISSN 1464-3405
Grant CEP: GA ČR GA203/09/1311; GA MŠMT 1M0520; GA ČR GAP303/11/1291
Grant ostatní: MŠMT(CZ) CZ.01.05/2.1.00/01.0030; GA AV ČR(CZ) KAN200100801; MPO(CZ) FR-TI3/521
Program: KA; FR
Výzkumný záměr: CEZ:AV0Z50520514
Institucionální podpora: RVO:68378050
Klíčová slova: porphyrinpolymethine * photodynamic therapy * apoptosis * cancer treatment
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.338, rok: 2012

A general method for the synthesis of a novel porphyrin with pentamethine periphery substitution is described. The combination of two chromophoric systems, a porphyrin macrocycle and a polymethine moiety was achieved by transformation of tetrapyridyl porphyrin. The synthetic strategy included conversion of the tetrapyridyl porphyrin to its corresponding 2,4-dinitrophenylpyridinuim salt, which was subsequently converted to tetrakis(meso-pentamethinium salt) on the porphyrin core. This novel porphyrin exhibited PDT properties as manifested by the induction of apoptosis in the myeloid cell line HL-60 and the effective reduction of amelanotic melanoma in nude mice.
Trvalý link: http://hdl.handle.net/11104/0216414