Core/Shell Nanofibers with Embedded Liposomes as a Drug Delivery System

0377767 - ÚEM 2013 RIV US eng J - Článek v odborném periodiku
Míčková, Andrea - Buzgo, Matej - Benada, Oldřich - Rampichová, Michala - Fišar, Z. - Filová, Eva - Tesařová, Martina - Lukáš, D. - Amler, Evžen
Core/Shell Nanofibers with Embedded Liposomes as a Drug Delivery System.
Biomacromolecules. Roč. 13, č. 4 (2012), s. 952-962. ISSN 1525-7797. E-ISSN 1526-4602
Grant CEP: GA MŠMT 2B06130; GA AV ČR(CZ) IAA500390702; GA ČR GAP304/10/1307
Grant ostatní: GA MŠk(CZ) MSM0021620849; GA MŠk(CZ) 4977751303; GA MŠk(CZ) GA UK 96610; GA MŠk(CZ) GA UK 80009; GA MŠk(CZ) GA UK 97110; GA MŠk(CZ) GA UK 330611; GA MŠk(CZ) GA UK 164010; MZd(CZ) NT12156; GA MŠk(CZ) ME10145; GA ČR(CZ) GA202/09/1151; GA MŠk(CZ) 1M0510
Program: GA; 1M
Výzkumný záměr: CEZ:AV0Z50390703; CEZ:AV0Z50390512; CEZ:AV0Z50200510; CEZ:AV0Z60220518
Institucionální podpora: RVO:60077344 ; RVO:61388971 ; RVO:68378041
Klíčová slova: tissue Engineering applications * electrospun nanofibers * liposomes
Kód oboru RIV: FP - Ostatní lékařské obory; BO - Biofyzika (MBU-M); BO - Biofyzika (BC-A)
Impakt faktor: 5.371, rok: 2012

We produced 2 different nanofiber-liposome systems in the present study: liposomes blended within nanofibers and core/shell nanofibers with embedded liposomes. We demonstrate that blend electrospinning does not conserve intact liposomes in contrast to coaxial electrospinning which enables the incorporation of liposomes into nanofibers. We report polyvinyl alcohol-core/poly-ε-caprolactone-shell nanofibers with embedded liposomes and show that they preserve the enzymatic activity of encapsulated horseradish peroxidase. The potential of this system was also demonstrated by the enhancement of mesenchymal stem cell proliferation.
Trvalý link: http://hdl.handle.net/11104/0007022