Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles

0377763 - ÚEM 2013 RIV GB eng J - Článek v odborném periodiku
Líbalová, Helena - Uhlířová, Kateřina - Kléma, J. - Machala, M. - Šrám, Radim - Ciganek, M. - Topinka, Jan
Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles.
Particle and Fibre Toxicology. Roč. 9, č. 1 (2012), s. 1-16. ISSN 1743-8977. E-ISSN 1743-8977
Grant CEP: GA MŠMT 2B08005; GA ČR GAP503/11/0142
Výzkumný záměr: CEZ:AV0Z50390512; CEZ:AV0Z50390703
Institucionální podpora: RVO:68378041
Klíčová slova: air pollution * complex mixtures * HEL cells
Kód oboru RIV: DN - Vliv životního prostředí na zdraví
Impakt faktor: 9.178, rok: 2012

Toxic effects of complex mixtures of organic extracts from urban particles (PM2.5) collected at 4 localities with different extent of air pollution (Ostrava-Bartovice, Ostrava-Poruba, Karviná a Třeboň) were evaluated. For this purpose, human embryonic lung fibroblasts (HEL 12469) were used. Global gene expression changes were analyzed using human whole genome microarrays (Illumina). The transcriptomic data did not differ substantially between the localities, suggesting that the air pollution originating mainly from various sources may have similar biological effects.
Trvalý link: http://hdl.handle.net/11104/0209837