Vitamin C for DNA damage prevention

0377753 - ÚEM 2013 RIV NL eng J - Článek v odborném periodiku
Šrám, Radim - Binková, B. - Rössner ml., Pavel
Vitamin C for DNA damage prevention.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Roč. 733, 1-2 (2012), s. 39-49. ISSN 0027-5107
Grant CEP: GA MŠMT 2B08005; GA MŽP(CZ) SP/1B3/50/07
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: Chromosomal aberrations * DNA adducts * DNA repair
Kód oboru RIV: DN - Vliv životního prostředí na zdraví
Impakt faktor: 3.902, rok: 2012

This review evaluates the human studies that used molecular epidemiology methods to investigate the ability of vitamin C to affect genetic damage. The protective effect of vitamin C was confirmed at plasma levels >50 μmol/l. The efect of vitamin C supplementation was studied in various study groups (subjects exposed to ionizing radiation, subjects occupationally or environmentally exposed to mutagens, to c-PAHs and PM2.5 in polluted air as well as smokers and poorly nourished subjects). It is possible that the impact of vitamin C on DNA damage depends both on background values of vitamin C in the individual as well as on the level of exposure to xenobiotics or oxidative stress.
Trvalý link: http://hdl.handle.net/11104/0209833