Počet záznamů: 1  

Stretching the Rules: Monocentric Chromosomes with Multiple Centromere Domains

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    0377728 - BC 2015 RIV US eng J - Článek v odborném periodiku
    Neumann, Pavel - Navrátilová, Alice - Schroeder-Reiter, E. - Koblížková, Andrea - Steinbauerová, Veronika - Chocholová, Eva - Novák, Petr - Wanner, G. - Macas, Jiří
    Stretching the Rules: Monocentric Chromosomes with Multiple Centromere Domains.
    PLoS Genetics. Roč. 8, č. 6 (2012), e1002777. ISSN 1553-7404. E-ISSN 1553-7404
    Grant CEP: GA ČR(CZ) GAP501/11/1843; GA ČR GBP501/12/G090; GA MŠMT(CZ) LH11058
    Výzkumný záměr: CEZ:AV0Z50510513
    Klíčová slova: Pisum sativum L. * Histone H3 * plant centromers * holocentric chromosomes
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 8.517, rok: 2012

    The centromere is a functional chromosome domain that is essential for faithful chromosome segregation during cell division and that can be reliably identified by the presence of the centromere-specific histone H3 variant CenH3. In monocentric chromosomes, the centromere is characterized by a single CenH3-containing region within a morphologically distinct primary constriction. This region usually spans up to a few Mbp composed mainly of centromere-specific satellite DNA common to all chromosomes of a given species. In holocentric chromosomes, there is no primary constriction; the centromere is composed of many CenH3 loci distributed along the entire length of a chromosome. Using correlative fluorescence light microscopy and high-resolution electron microscopy, we show that pea (Pisum sativum) chromosomes exhibit remarkably long primary constrictions that contain 3–5 explicit CenH3-containing regions, a novelty in centromere organization.
    Trvalý link: http://hdl.handle.net/11104/0209820

     
     
Počet záznamů: 1  

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