Proteasomal degradation of ubiquitinated proteins in oocyte meiosis and fertilization in mammals

0377696 - ÚŽFG 2013 RIV DE eng J - Článek v odborném periodiku
Karabínová, Pavla - Kubelka, Michal - Šušor, Andrej
Proteasomal degradation of ubiquitinated proteins in oocyte meiosis and fertilization in mammals.
Cell and Tissue Research. Roč. 346, č. 1 (2011), s. 1-9. ISSN 0302-766X. E-ISSN 1432-0878
Grant CEP: GA ČR GAP502/10/0944; GA ČR(CZ) GD204/09/H084
Výzkumný záměr: CEZ:AV0Z50450515
Klíčová slova: Oocyte * Proteasome * Meiosis
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.114, rok: 2011

Gametogenesis and fertilization are the key events in sexual reproduction. In the female, meiosis results in a large oocyte that is competent for fertilization and fundamental for the success of early embryonic development. Progression through meiosis is monitored by fine regulatory mechanisms. In this review, we focus on one of the most well-known regulatory elements, the E3 ligase APC/C, which mediates proteolytic degradation of a number of important substrates via the ubiquitin proteasome pathway (UPP). The UPP also indirectly regulates protein synthesis by affecting proteins involved in RNA metabolism, a process that is paramount for the transcriptionally silent oocyte. During the past few years, more evidence has accumulated to suggest that the UPP has an important role in zona pellucida penetration and gamete fusion in mammals. This review focuses on the function of the UPP in regulating oocyte meiotic maturation in mammals, with special attention to its role in chromosome segregation and polar body extrusion, its role in the acquisition of meiotic/developmental competence and recent advances in our understanding of the UPP role in fertilization.
Trvalý link: http://hdl.handle.net/11104/0209791