Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension

0377329 - FGÚ 2013 RIV GB eng J - Článek v odborném periodiku
Neckář, Jan - Kopkan, L. - Husková, Z. - Kolář, František - Papoušek, František - Kramer, H. J. - Hwang, S.H. - Hammock, B.D. - Imig, J. D. - Malý, J. - Netuka, I. - Ošťádal, Bohuslav - Červenka, L.
Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.
Clinical science. Roč. 122, č. 11 (2012), s. 513-525. ISSN 0143-5221. E-ISSN 1470-8736
Grant CEP: GA AV ČR(CZ) IAAX01110901; GA AV ČR(CZ) KAN200520703; GA MŠMT(CZ) 1M0510
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: hypertension * angiotensin II * kidney * epoxyeicosatrienoic acids * soluble epoxide hydrolase inhibitor * myocardial ischemia/reperfusion injury
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 4.859, rok: 2012

The present study was undertaken to evaluate the effects of chronic treatment with c-AUCB, a novel inhibitor of soluble epoxide hydrolase (sEH) which is responsible for the conversion of biologically active epoxyeicosatrienoic acids to biologically inactive dihydroxyeicosatrienoic acids, on blood pressure and myocardial infarct size in male heterozygous Ren-2 transgenic rats with established hypertension. Our findings indicate that chronic inhibition of sEH exhibits antihypertensive and cardioprotective actions in this transgenic model of angiotensin II-dependent hypertension
Trvalý link: http://hdl.handle.net/11104/0209513