0377147 - FGÚ 2013 RIV GB eng J - Článek v odborném periodiku
Ortega, F.J. - Jílková, Zuzana - Moreno-Navarrete, J.M. - Pavelka, S. - Rodriguez-Hermosa, J.I. - Kopecký, Jan - Fernández-Real, J.M.
Type I iodothyronine 5′-deiodinase mRNA and activity is increased in adipose tissue of obese subjects.
International Journal of Obesity. Roč. 36, č. 2 (2012), s. 320-324. ISSN 0307-0565. E-ISSN 1476-5497
Grant CEP: GA MŠMT(CZ) OC08008
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: adipose tissue * thyroid hormones * deiodinases * tissue expression * enzyme activity
Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
Impakt faktor: 5.221, rok: 2012

Differentiation and metabolism of adipose tissue are modulated by thyroid hormones (THs), but relatively little is known about the metabolism of THs in this tissue. Our results document increased D1 gene expression and activity in adipose tissue of obese humans and suggest a role of 3,5,30-triiodo-L-thyronine formed by D1 in response to leptin in the modulation of adipose tissue metabolism
Trvalý link: http://hdl.handle.net/11104/0209388