Brain superoxide anion formation in immature rats during seizures: Protection by selected compounds

0376883 - FGÚ 2013 RIV US eng J - Článek v odborném periodiku
Folbergrová, Jaroslava - Otáhal, Jakub - Druga, Rastislav
Brain superoxide anion formation in immature rats during seizures: Protection by selected compounds.
Experimental Neurology. Roč. 233, č. 1 (2012), s. 421-429. ISSN 0014-4886. E-ISSN 1090-2430
Grant CEP: GA ČR GA309/08/0292; GA ČR GAP303/10/0999
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: immature rats * DL-homocysteic acid-induced seizures * superoxide anion * SOD mimetics * protection * Fluoro-Jade B staining * brain damage
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 4.645, rok: 2012

The present findings provide the evidence of oxidative stress in brain of immature rats during seizures induced by DL-homocysteic acid.The enhanced O-2 center dot(-)production was significantly attenuated or completely prevented by substances providing an anticonvulsant effect and by selected SOD mimetics.The increased O-2 center dot(-)generation precedes neuronal degeneration and may thus play a causative role in neuronal injury
Trvalý link: http://hdl.handle.net/11104/0209178