The role of sympathetic nervous system in the development of neurogenic pulmonary edema in spinal cord-injured rats

0376805 - FGÚ 2013 RIV US eng J - Článek v odborném periodiku
Šedý, Jiří - Zicha, Josef - Nedvídková, J. - Kuneš, Jaroslav
The role of sympathetic nervous system in the development of neurogenic pulmonary edema in spinal cord-injured rats.
Journal of Applied Physiology. Roč. 112, č. 1 (2012), s. 1-8. ISSN 8750-7587. E-ISSN 1522-1601
Grant CEP: GA MŠMT(CZ) 1M0510; GA ČR(CZ) GA305/08/0139; GA AV ČR(CZ) IAA500110902
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: neurogenic pulmonary edema * sympathetic nervous system * baroreflex
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 3.484, rok: 2012

We examined whether the development of neurogenic pulmonary edema (NPE) in rats with balloon compression of spinal cord is a consequence of rapid activation of spinal pathways leading to sympathetic venoconstriction, blood pressure rise, and reflex bradycardia. We demonstrated that considerable activation of thoracic spinal pathways, followed by marked catecholamine secretion, play a major role in the development of NPE in spinal cord-injured rats. Enhanced α-adrenergic nifedipine-sensitive vasoconstriction is responsible for observed blood pressure changes, subsequent baroreflex bradycardia, and blood volume redistribution, which represent major pathogenetic mechanisms of NPE development
Trvalý link: http://hdl.handle.net/11104/0209115