Cellular response to antitumor cis-dichlorido platinum(II) complexes of CDK inhibitor bohemine and its analogues

0376804 - BFÚ 2013 RIV US eng J - Článek v odborném periodiku
Lišková, Barbora - Zerzánková, Lenka - Nováková, Olga - Kostrhunová, Hana - Trávníček, Z. - Brabec, Viktor
Cellular response to antitumor cis-dichlorido platinum(II) complexes of CDK inhibitor bohemine and its analogues.
Chemical Research in Toxicology. Roč. 25, č. 2 (2012), s. 500-509. ISSN 0893-228X. E-ISSN 1520-5010
Grant CEP: GA ČR(CZ) GD301/09/H004; GA ČR(CZ) GAP301/10/0598
Klíčová slova: cisplatin * DNA * bohemine
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 3.667, rok: 2012

The cellular and molecular pharmacology of the new class of anticancer drugs, in which CDK inhibitor bohemine and its analogues are coordinated to Pt(II) to form cisplatin derivatives, was investigated. The results revealed the unique anticancer profile of a cisplatin-derived platinum(II) dichlorido complex involving N(7)-coordinated bohemine (C1). The results also showed that the distinct differences in cell killing observed for C1 and cisplatin might be associated with processes at the DNA level. It was concluded that C1 remains a promising prototype of compounds for the generation of novel drug candidates with cytotoxicity profiles different from those of platinum drugs currently in use.
Trvalý link: http://hdl.handle.net/11104/0209114