Nucleophilic additions of [(diethoxyphosphoryl)difluoromethyl]lithium to a,b-unsaturated compounds

0376749 - ÚOCHB 2013 RIV CH eng J - Článek v odborném periodiku
Cherkupally, Prabhakar - Beier, Petr
Nucleophilic additions of [(diethoxyphosphoryl)difluoromethyl]lithium to a,b-unsaturated compounds.
Journal of Fluorine Chemistry. Roč. 137, May (2012), s. 34-43. ISSN 0022-1139. E-ISSN 1873-3328
Grant CEP: GA ČR GP203/08/P310
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: 1,4-Addition * nucleophilic addition * difluoromethylphosphonate
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 1.939, rok: 2012

The presence of HMPA leads to an increase of 1,4- versus 1,2-additions of [(diethoxyphosphoryl)difluoromethyl] lithium onto a,b-unsaturated ketones and provides products of conjugated addition in moderate to good yields. In the absence of HMPA, benzylidine or alkylidine 1,3-diones, malononitriles or malonates as well as nitroalkenes and other Michael acceptors give products of 1,4-addition in good to high yields.
Trvalý link: http://hdl.handle.net/11104/0209073