Počet záznamů: 1
Boron Science: New Technologies and Applications
- 1.0376636 - ÚOCHB 2013 RIV US eng M - Část monografie knihy
Řezáčová, Pavlína - Cígler, Petr - Matějíček, P. - Lepšík, Martin - Pokorná, Jana - Grüner, Bohumír - Konvalinka, Jan
Medicinal Application of Carboranes Inhibition of HIV Protease.
Boron Science: New Technologies and Applications. Boca Raton: CRC Press, 2012, s. 41-70. ISBN 978-1-4398-2662-1
Grant CEP: GA AV ČR IAAX00320901; GA MŠMT LC512; GA MŠMT LC523
Grant ostatní: 6th Framework(XE) QLRT2001-02360
Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z40320502
Klíčová slova: metallacarboranes * resistance * inhibitor * HIV * AIDS
Kód oboru RIV: CE - Biochemie
The aspartic protease of human immunodeficiency virus (HIV PR) is one of the most extensively studied enzymes known to man. The successful rational design of HIV PIs is one of the most striking examples of structure-based drug design. In this chapter, we will explain why the design of novel, potent PIs is still urgently needed and that derivatives of boron community well known cobalt bis(dicarbollide)(1-) ion [(1,2-C2B9H11)-3,3'-Co(III)](1-) (Hawthorne, 1965, Sivaev 1999) can act as unexpected class of specific HIV PIs. We shall review their activity, specificity, mechanism of action, and binding mode to HIV protease.
Trvalý link: http://hdl.handle.net/11104/0208988
Počet záznamů: 1