Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease.

0375584 - ÚEM 2012 RIV GB eng J - Článek v odborném periodiku
Yeh, C. Y. - Vadhwana, B. - Verkhratsky, Alexei - Rodríguez Arellano, Jose Julio
Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease.
ASN Neuro. Roč. 3, č. 5 (2011), e00071. ISSN 1759-0914. E-ISSN 1759-0914
Grant CEP: GA ČR GA309/09/1696; GA ČR(CZ) GAP304/11/0184; GA ČR GA305/08/1384; GA ČR GA309/08/1381
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: Alzheimer's disease * astrocyte * dementia
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.750, rok: 2011

Our results suggest that cognitive deterioration during the progression of the Alzheimer disease can be associated with an early reduction of astrocytic arborization and shrinkage of the astroglial domain, which may affect synaptic connectivity within the EC and between the EC and other brain regions. Additionally, the EC seems to be particularly vulnerable to AD pathology because of the absence of evident astrogliosis in response to Ab accumulation.
Trvalý link: http://hdl.handle.net/11104/0208196