Anti-Angiogenesis Drug Discovery and Development

0375398 - ÚOCHB 2012 RIV IN eng M - Část monografie knihy
Nencka, Radim
Thymidine Phosphorylase Inhibitors.
Anti-Angiogenesis Drug Discovery and Development. Karachi: Bentham Science Publishers, 2011 - (Atta-ur-Rahman, F.; Choudhary, M.), s. 116-147. ISBN 978-1-60805-162-5
Grant CEP: GA MŠMT 1M0508; GA AV ČR 1QS400550501
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: thymidine phosphorylase inhibitors * angiogenesis * cancer chemotherapy
Kód oboru RIV: CC - Organická chemie

Thymidine phosphorylase (TP) is an enzyme that acts as a proangiogenic factor. Overexpression of the enzyme was observed in various solid tumors and several chronic inflammatory diseases, where it was correlated with level of angiogenesis and elevated progression of the disease. TP inhibitors are compounds designed to interfere with the processes connected with catalytic function of this enzyme including TP-mediated angiogenesis and the degradation of important antiviral and anticancer drugs. This chapter comprehensively reviews the hitherto known TP inhibitors with further insight into their potential applications in the clinical practices.
Trvalý link: http://hdl.handle.net/11104/0208061