0375208 - MBÚ 2012 RIV CZ eng A - Abstrakt
Schwarzer, Martin - Repa, A. - Schabussova, I. - Šrůtková, Dagmar - Daniel, C. - Pot, B. - Štěpánková, Renata - Hudcovic, Tomáš - Hrnčíř, Tomáš - Tlaskalová-Hogenová, Helena - Wiedermann, U. - Kozáková, Hana
Neonatal colonization of mice with probiotic bacteria: Impact on systemic sensitization to aeroallergen Bet v 1.
Sborník přednášek VI. sympozia Společnosti pro probiotika a prebiotika. Praha: ČZU Praha, 2011. s. 22-23. ISBN 978-80-213-2173-1.
[Sympozium Společnosti pro probiotika a prebiotika /6./. 19.04.2011, Praha]
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: germ-free mice * allergy
Kód oboru RIV: EC - Imunologie

Mono-colonization of mice with the Bet v 1 producing L. plantarum induced a Th1-biased immune response at the cellular level and reduced levels of Bet v 1 specific antibodies in sera, while wild type strain had no such effect. On the other hand, B. longum strain supressed cytokine production as well as specific antibody production. In vitro we showed different immunomodulatory properties of these two strains with different signalling through TLR receptors. We speculate that strong Th1 inducers like L. plantarum are able to modulate the systemic sensitization in vivo only when administrated together with the allergen. On the other hand, moderately stimulating probiotics such as B. longum ssp. longum are able to suppress the sensitization in a different way by inducing Treg bias
Trvalý link: http://hdl.handle.net/11104/0207931