Polymeric micelles with doxorubicin bound through hydrazon bond - A new promising antitumor drug delivery system

0375205 - MBÚ 2012 RIV CH eng A - Abstrakt
Větvička, David - Hovorka, Ondřej - Hrubý, Martin - Mrkvan, Tomáš - Ulbrich, Karel - Říhová, Blanka
Polymeric micelles with doxorubicin bound through hydrazon bond - A new promising antitumor drug delivery system.
TUMOR BIOLOGY. BASEL: KARGER, 2007. -, -, s. 88-88. ISSN 1010-4283.
[Meeting of the International Society for Oncodevelopmental Biology and Medicine, ISOBM 2007 /35./. 15.09.2007-19.09.2007, Prague]
Grant CEP: GA AV ČR KAN200200651
Výzkumný záměr: CEZ:AV0Z50200510; CEZ:AV0Z40500505
Klíčová slova: doxorubicin * polymeric micelles * drug
Kód oboru RIV: EC - Imunologie

The work deals of polymeric micelles with doxorubicin bound through hydrazon bond- a new promising antitumour drug delivery system. One of the promising approaches in the therapy of ulcerative colitis is administration of butyrate, an energy source for colonocytes, into the lumen of the colon. This study investigates the effect of butyrate producing bakterium Clostridium tyrobutyricum on dextran sodium sulphate (DSS)-induced colitis in mice. Immunocompetent BALB/c and immunodeficient severe combined immunodeficiency (SCID) mice reared in specific-pathogen-free (SPF) conditions were treated intrarectally with C. tyrobutyricum 1 week prior to the induction of DSS colitis and during oral DSS treatment.
Trvalý link: http://hdl.handle.net/11104/0207930