0374557 - ÚFE 2012 RIV US eng J - Článek v odborném periodiku
Kvasnička, Pavel - Chadt, Karel - Vala, Milan - Bocková, Markéta - Homola, Jiří
Toward single-molecule detection with sensors based on propagating surface plasmons.
Optics Letters. Roč. 37, č. 2 (2012), s. 163-165. ISSN 0146-9592. E-ISSN 1539-4794
Grant CEP: GA AV ČR KAN200670701; GA MŠMT OC09058; GA MŠMT(CZ) LH11102
Výzkumný záměr: CEZ:AV0Z20670512
Klíčová slova: optical biosenzor * single molecule * surface plasmon microscopy
Kód oboru RIV: JA - Elektronika a optoelektronika, elektrotechnika
Impakt faktor: 3.385, rok: 2012 ; AIS: 1.151, rok: 2012
DOI: https://doi.org/10.1364/OL.37.000163

Surface plasmon resonance (SPR) sensors are known to be able to detect very low surface concentrations of (bio) molecules on macroscopic areas. To explore the potential of SPR biosensors for single-molecule detection, we have minimized the read-out area (to ~64 μm2) in a sensor generating SPs on a grating via a microscope objective and collecting light through a small aperture. Results suggest that as few as ~500 proteins could be detected by the sensor (3 orders of mag. lower than state-of-art).
Trvalý link: http://hdl.handle.net/11104/0207453