Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy

0372591 - FGÚ 2012 RIV GB eng J - Článek v odborném periodiku
Špicarová, Diana - Nerandžič, Vladimír - Paleček, Jiří
Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy.
Journal of Neuroinflammation. Roč. 8, - (2011), e177. E-ISSN 1742-2094
Grant CEP: GA ČR(CZ) GA305/09/1228; GA MŠMT(CZ) LC554
Grant ostatní: Univerzita Karlova(CZ) 309211
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: TNF * neuropathy * pain
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.827, rok: 2011

The cytokine tumor necrosis factor a (TNFa) is an established pain modulator in both the peripheral and central nervous systems. Modulation of nociceptive synaptic transmission in the spinal cord dorsal horn (DH) is thought to be involved in the development and maintenance of several pathological pain states. Increased levels of TNFa and its receptors (TNFR) in dorsal root ganglion (DRG) cells and in the spinal cord DH have been shown to play an essential role in neuropathic pain processing. In the present experiments the effect of TNFa incubation on modulation of primary afferent synaptic activity was investigated in a model of peripheral neuropathy
Trvalý link: http://hdl.handle.net/11104/0205869